Below is a list of the current characters and recently departed characters of Holby City. There are currently 17 regular cast members in the show. The oldest cast member is Hugh Quarshie who plays Ric Griffin, who made his first appearance in September 2001. Note that "first appearance" doesn't necessarily mean they became a regular on the show at this point, as it could have just been a guest appearance.
- Main article: Ric Griffin
Ric Griffin is a Consultant General Surgeon and AAU Deputy Clinical Lead. He is also the former acting CEO of Holby City Hospital.
Ric is a moral and principled man of the NHS, he is an idealistic crusader who would take on any man for something he believes in. Ric is an excellent surgeon, a noble and selfless medical hero.
But with fractured family relationships and a string of broken marriages behind him, sometimes Ric regrets bearing the weight of the world on his shoulders.
- Main article: Donna Jackson
Donna Jackson is a Senior Staff Nurse, who is currently working on AAU at Holby City Hospital.
Donna arrived at Holby City Hospital in 2004, she left the wards of Holby City in 2011. Donna returned back to Holby's AAU ward in June 2017.
- Main article: Jac Naylor
Jacqueline "Jac" Naylor (born 19 April) is a consultant cardiothoracic surgeon and the current Lead Consultant in Cardiothoracics of Holby City Hospital. She initially joined the hospital's Keller Ward in 2005 as a general surgical registrar, but transferred to Darwin to specialise in cardiothoracics in 2008. In 2011, she became a consultant cardiothoracic surgeon, and went on to become the Clinical Lead three years later.
In 2005, she was initially unsuccessful in obtaining the permanent registrar post, but returned just weeks later having been offered the job. Following her job offer, she immediately made a large impact on the other members of staff. In the following years at the hospital, she had relationships with several other staff members including Joseph Byrne, Lord Byrne, Jonnie Maconie and Guy Self. In 2014, she gave birth to a daughter, Emma, with Jonnie Maconie.
- Main article: Sacha Levy
Sacha Levy (born 6 September 1966) is a consultant general surgeon who currently works on the Keller Ward of Holby City Hospital.
A lovable bear of a man, Sacha Levy's capacity to enjoy life is equalled only by his compassion, he works to live and lives to help people, not to climb the greasy pole. But don't let the laid back jocular exterior fool you! Underneath this larger-than-life facade beats a lion's heart, deftly protecting all that he holds dear.
Frieda PetrenkoFrieda Petrenko (born 28 September 1980) is a doctor who worked at Holby City Hospital from 2010 to 2012 and again From 2017.
Frieda is a goth and often gets comments from staff and patients about her appearence.
Frieda returned as a cardiothoracic registrar on 12 December 2017 and her first job is to operate on Jac Naylor, who's recovering from being shot but has developed cardiac tamponade.
- Main article: Henrik Hanssen
Henrik Love Hanssen (né Lövborg) is a consultant in general surgery and a former Chief Executive Officer of Holby City Hospital.
Highly intellectual and enigmatic, Swedish-born Hanssen is the epitome of an exceptional leader with razor-sharp focus and meticulous surgical skill. Hanssen’s aloof manner and dry wit belie an often perceptive and compassionate nature but he would never dream of revealing any private moments of weakness. An omniscient and steadfast presence, Holby is safe in
- Main article: Serena Campbell
Serena Wendy Campbell (born 1 October) is a consultant general surgeon and current Clinical Lead of Holby City Hospital's Acute Admissions Unit. She joined the hospital on its Keller Ward in March 2012, and transferred to AAU after.
Charmingly candid and utterly professional, Serena has arrived at Holby to shake up the old order. Unlike many of her contemporaries she has an outstanding business brain, with a Harvard MBA under her belt.
Equally at home in the boardroom or in theatre, she is an unapologetic achiever and fearless architect of change. Wielding her iron fist in an exquisite velvet glove, Serena is a force to be reckoned with.
- Main article: Dominic Copeland
Dominic "Dom" Copeland is a Specialist Registrar in General Surgery who currently works on the Keller Ward of Holby City Hospital.
Troubled and trouble in equal measure, Dom's a wily schemer who is always working an angle. Intelligent and sharp-witted, he's actually very sensitive and is easily wounded, often believing himself to be the victim and justifying his actions as self-defence.
Fiercely protective of, and generous towards, those he favours, Dom can also be surly and vindictive towards those he feels have betrayed him. When it comes to fact versus fiction, Dom prefers to glamorise.
Complicated, unpredictable and deliciously wicked, one thing’s for sure: things are a lot more interesting when Dom's around.
Adrian "Fletch" Fletcher
- Main article: Adrian "Fletch" Fletcher
Adrain "Fletch" Fletcher is the current Director of Nursing of Holby City Hospital. He joined AAU as Ward Manager in 2014 shortly after departing his job as a senior staff nurse in the hospital's Emergency Department.
Straight-talking and nobody’s fool, Fletch can dish out tough love when he needs to, but behind it he’s as big-hearted as they come; a dedicated dad always willing to go the extra mile for those in need…
Essie Di Lucca
- Main article: Essie Harrison
Estelle "Essie" Harrison (also Di Lucca) is a staff nurse at Holby City Hospital, she first arrived on the 6 May 2014.
As a female friend, she's a rock – there’s no earthly wrong that a bucket of wine and a drunken dance can’t right. As a girlfriend, she’s spontaneous, emboldening and fun, though secretly struggles with the fact that Sacha has two demanding ex-wives and three children. Essie’s independence is sometimes a threat to Sacha; he likes to feel depended upon.
In turn, Sacha is driven nuts by her slatternly domestic ways. Essie leaves a trail of girly devastation whenever she gets ready to go out. It reminds him of his daughters!
Ben "Lofty" Chiltern
- Main article: Ben "Lofty" Chiltern
Benjamin "Lofty" Chiltern is a staff nurse who started working on the Keller Ward of Holby City Hospital in May 2017 and transferred to AAU later. He initially worked in the hospital's emergency department from 2014 to 2016.
Roxanna MacMillanRoxanna MacMillan is the clinical lead of Darwin Neurosurgical Unit and a consultant neurosurgeon who started working at Holby City Hospital on 24 October 2017. She had previously worked there in 2013.
John GaskellProfessor John Gaskell is a professor of neurosurgery and the Director of Surgical Innovations who started working on the neurosurgical unit of Darwin Ward of Holby City Hospital on 5 December 2017. In March 2017 John became Medical Director of the hospital
Abigail TaitAbigail Tate is a consultant cardiothoracic surgeon, Chief Executive Officer of Holby City Hospital and the current Acting Clinical Lead of Darwin. She joined the hospital as CEO in April 2018, replacing Henrik Hanssen following his resignation in March 2018. Abigail is a close friend of Serena Campbell.
(first appearance as series regular)
|Ric Griffin||Hugh Quarshie||Deputy Lead Consultant in Surgical Admissions and Consultant General Surgeon||AAU||9 October 2001||16 years, 9 months and 10 days|
|Donna Jackson||Jaye Jacobs||Senior Staff Nurse||AAU||16 March 2004||14 years, 4 months and 3 days|
|Jac Naylor||Rosie Marcel||Director of Cardiothoracics and Consultant Cardiothoracic Surgeon||Darwin||22 November 2005||12 years, 7 months and 27 days|
|Sacha Levy||Bob Barrett||Lead Consultant in General Surgery, Consultant General Surgeon and Clinical Skills Tutor||Keller||5 January 2010||8 years, 6 months and 14 days|
|Henrik Hanssen||Guy Henry||Consultant General Surgeon||Keller||19 October 2010||7 years and 9 months|
|Serena Campbell||Catherine Russell||Lead Consultant in Surgical Admissions||AAU||1 May 2012|
|Dominic Copeland||David Ames||Specialist Registrar, General Surgery||Keller||14 January 2014||4 years, 6 months and 5 days|
|Adrian Fletcher||Alex Walkinshaw||Director of Nursing||Darwin||12 August 2014||3 years, 11 months and 7 days|
|Ben Chiltern||Lee Mead||Staff Nurse||AAU||16 May 2017||1 year, 2 months and 3 days|
|Roxanna MacMillan||Hermione Guildford||Clinical Lead (Neurosurgical Unit), Consultant Neurosurgeon||Neurosurgical Unit (Darwin)||24 October 2017||8 months and 25 days|
|John Gaskell||Paul McGann||Professor of Medicine, Director of Surgical Innovation||Neurosurgical Unit (Darwin)||5th December 2017||4 Months and 138 days.|
|Abigail Tate||Olivia Poulet||Cheif Executive Officer, Deputy Clinical Lead (Darwin), Consultant Cardiothoracic Surgeon||Darwin||3rd April 2018||0 Months and 12 days|