Roxanna MacMillan is a consultant neurosurgeon and the current Neurology Clinical Lead at Holby City Hospital. She first worked at the hospital as a locum in April 2013 and began working there on a permanent basis in October 2017.
Roxanna worked in the hospital until 2013 after her unsuccesful operation on Darwin F1 Tara Lo, which resulted in the latter's death.
Roxanna returned on 24 October 2017 and tries to rebuild her bridges with Tara's husband and cardiothoracic registrar Oliver Valentine. Both Roxanna and Oliver pitch for the funding of their research projects. Roxanna is developing a virutal reality device meant for dementic patients. As Roxanna's husband, professor David Hopkins has dementia, Oliver feels for them and persuades medical director Nina Karnik to give the funding to her project.
Oliver is frustrated to find out that Roxanna cancelled her project but soon finds out it was because David's dementia has already developed too much and the project isn't possible to use on him. David suffers from PVO which Oliver operates on, assisted by AAU CT1 Morven Digby and observed by Roxanna. Oliver gets shot by Fredrik Johanssen while operating and as David develops a cerebal bleed, Morven convinces Roxanna to operate on Oliver who has been shot to the head. As Roxanna is operating, David goes into venticular fibrillation and resusciation proves unsuccesful.3 weeks after the shooting, Roxanna is ready to wake Oliver up from his enduced coma, but it is too soon for Oliver and he is kept in coma for more.