House officer Victoria Merrick attempts to conquer her nerves on her first day at Holby, and Julie has difficulty reconciling her personal life with her night shifts, while Jasmine Hopkins is called on to use all her diplomatic skills.
The staff of Darwin ward struggle to prevent a deadly infection spreading beyond the confines of Casualty's famous hospital, while Dr Kirstie Collins inadvertently discovers Nick Jordan has a dark secret.
Coma girl Nicola contracts pneumonia - leaving doctors McKendrick and Collins to help her parents make an agonising decision. Anton Meyer faces an unusual problem with a transplant patient, and on the ward, the staff are delighted to hear that at least one person loves them.
An emergency forces Victoria to think on her feet to bring a patient back from the brink of death and Nick is the victim of consultant surgeon Mr Meyer's razor-sharp tongue as they fight to save a baby born with a heart defect.
Nick's delay in attending a call results in the patient's death. To add to his problems, he then has to ask the victim's parents about the possibility of organ donation : but all they want to know is how such a minor injury could have led to their son's demise.
Part one of two. Sunny offers Victoria moral guidance, and comes up trumps in a radio quiz. Jordan and Meyer find themselves under increasing pressure, while Muriel McKendrick encounters a former colleague who proves a bit of a handful as a patient.